Preparation of some prostaglandin E1 and omega-homo-prostaglandin E1 esters and their inhibiting properties on rat blood platelet aggregation

L van der Wolf; J Kloeze; H J Pabon; D A van Dorp

doi:10.1016/0090-6980(78)90145-4

Preparation of some prostaglandin E1 and omega-homo-prostaglandin E1 esters and their inhibiting properties on rat blood platelet aggregation

Prostaglandins. 1978 May;15(5):795-801. doi: 10.1016/0090-6980(78)90145-4.

Authors

L van der Wolf, J Kloeze, H J Pabon, D A van Dorp

PMID: 704904
DOI: 10.1016/0090-6980(78)90145-4

Abstract

Various esters of omega-homo-prostaglandin E1 and prostaglandin E1 were prepared in a yield of 28-55% to investigate their effect on ADP-induced aggregation of rat blood platelets. The biopotency of the omega-homo-PGE1-esters is about four times higher than that of the corresponding PGE1-esters. Furthermore, the biopotency of aliphatic esters decreases with increasing chain length of the ester group.

MeSH terms

Animals
In Vitro Techniques
Methods
Platelet Aggregation / drug effects*
Prostaglandins E, Synthetic / chemical synthesis*
Prostaglandins E, Synthetic / pharmacology
Rats

Substances

Prostaglandins E, Synthetic