4-N-Aminoacylation of substances derived from lysinomicin

J Antibiot (Tokyo). 1982 Oct;35(10):1338-44. doi: 10.7164/antibiotics.35.1338.

Abstract

The preparations of 4-N-glycyllysinomicin and several 4-N-aminoacyl derivatives of compounds prepared from lysinomicin are presented. The new substances have lower antimicrobial activities than the original 4-N-unsubstituted lysinomicin derivatives. This result indicates that the structure-activity relationship observed with fortimicin A and fortimicin B does not apply to the lysinomicin derivatives studied.

MeSH terms

  • Acylation
  • Aminoglycosides / chemical synthesis
  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • Magnetic Resonance Spectroscopy
  • Structure-Activity Relationship

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • lysinomicin
  • 4-N-glycyllysinomicin