Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer

Cancer Treat Rep. 1981 Jul-Aug;65(7-8):555-62.

Abstract

BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0 degrees C and 12 mins at 37 degrees C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carmustine / administration & dosage
  • Carmustine / blood*
  • Drug Administration Schedule
  • Female
  • Half-Life
  • Humans
  • Kinetics
  • Lung Neoplasms / blood*
  • Lung Neoplasms / drug therapy
  • Male
  • Middle Aged
  • Polarography / methods

Substances

  • Carmustine