[Calcium metabolism study performed by means of Ca-45 in bone diseases and idiopathic hypercalciuria]

Rev Rhum Mal Osteoartic. 1980 Dec;47(12):699-706.
[Article in French]

Abstract

The authors analyse the results obtained during 54 radioisotope investigations using 45Ca in 13 cases of idiopathic hypercalciuria, 12 cases of osteoporosis, 3 cases of Paget's disease, and 2 cases of osteomalacia including one of Fanconi's disease in an adult. In 12 patients, repetition of the radio-isotope test two, three or four times; permitted the authors to study the effects of the treatments administered: calcitonin, phosphate, vitamin D, parathormon, oestrogen. Calcitonin increases intestinal absorption and reduces bone reabsorption and also accretion. Phosphate greatly increases accretion and bone reabsorption in vitamin-resistant osteomalacia of adults. The synthetic fragment 1--34 of human parathormone increases accretion and reabsorption but does not modify the calcium balance. The addition of estrogen reduces reabsorption and slightly increases accretion in two osteoporotic patients producing a positive calcium balance. This method of investigation is of great interest to assess the effects of a drug on calcium metabolism and on the two processes of bone remodelling.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Bone Diseases / drug therapy
  • Bone Diseases / metabolism*
  • Calcitonin / therapeutic use
  • Calcium / metabolism*
  • Calcium / urine
  • Calcium Metabolism Disorders / drug therapy
  • Calcium Metabolism Disorders / metabolism*
  • Calcium Radioisotopes
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteitis Deformans / metabolism
  • Osteomalacia / metabolism
  • Osteoporosis / metabolism

Substances

  • Calcium Radioisotopes
  • Calcitonin
  • Calcium