Gene therapy to restore prostacyclin presence to injured endothelium

Trans Am Clin Climatol Assoc. 1995:106:100-7; discussion 107-8.

Abstract

These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the possibility of inhibiting thrombus development by adenovirus-CMV-PGHS-1 therapy in the initial 10 days following angioplasty.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenoviridae / genetics
  • Animals
  • Carotid Arteries / metabolism
  • Carotid Artery Injuries
  • Coronary Disease / metabolism
  • Coronary Disease / therapy
  • Endothelium, Vascular / injuries*
  • Endothelium, Vascular / metabolism*
  • Epoprostenol / metabolism*
  • Genetic Therapy / methods*
  • Humans
  • Prostaglandin-Endoperoxide Synthases / genetics
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Swine

Substances

  • Epoprostenol
  • Prostaglandin-Endoperoxide Synthases