Abstract
These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the possibility of inhibiting thrombus development by adenovirus-CMV-PGHS-1 therapy in the initial 10 days following angioplasty.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenoviridae / genetics
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Animals
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Carotid Arteries / metabolism
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Carotid Artery Injuries
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Coronary Disease / metabolism
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Coronary Disease / therapy
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Endothelium, Vascular / injuries*
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Endothelium, Vascular / metabolism*
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Epoprostenol / metabolism*
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Genetic Therapy / methods*
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Humans
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Prostaglandin-Endoperoxide Synthases / genetics
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Prostaglandin-Endoperoxide Synthases / metabolism
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Swine
Substances
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Epoprostenol
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Prostaglandin-Endoperoxide Synthases