Abstract
We have investigated the correlation between the prevalence of hepatitis C virus (HCV), which is detectable in saliva, and oral cancer and other digestive tract cancers in the Northern Kyushu region of Japan. Anti-HCV antibodies were detected in sera from 24 of the 100 patients with oral cancer (24%, p < 0.05 vs the control group, p < 0.01 vs the stomach cancer group), in 11 of 104 patients with non-malignant diseases receiving dental treatment (the control group, 10.6%), and in 12 of 113 patients with stomach cancer (10.6%). HCV-RNA was detected in sera from 17 of 100 oral cancer patients (17%, p < 0.05 vs the control group) and 4 of 104 patients of the control group (3.9%). These results indicate a high prevalence of HCV infection in oral cancer patients, which warrants a systematic study of etiological associations between oral cancer and HCV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / immunology
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Carcinoma, Squamous Cell / virology
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Child
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Colonic Neoplasms / genetics
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Colonic Neoplasms / immunology
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Colonic Neoplasms / virology
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Dental Caries / virology
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Esophageal Neoplasms / genetics
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Esophageal Neoplasms / immunology
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Esophageal Neoplasms / virology
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Female
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Hepacivirus / genetics*
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Hepacivirus / isolation & purification
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Hepatitis C Antibodies / blood*
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Humans
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Japan
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Male
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Middle Aged
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Mouth Neoplasms / genetics
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Mouth Neoplasms / immunology
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Mouth Neoplasms / virology*
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Periodontal Diseases / virology
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Prevalence
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RNA, Viral / analysis*
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Saliva / virology
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Stomach Neoplasms / genetics
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Stomach Neoplasms / immunology
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Stomach Neoplasms / virology
Substances
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Hepatitis C Antibodies
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RNA, Viral