Disposition of maternal ketoconazole in breast milk

Am J Obstet Gynecol. 1995 Nov;173(5):1625-6. doi: 10.1016/0002-9378(95)90662-2.

Abstract

Infant exposure to ketoconazole in human milk was calculated to be 0.4% on average (maximum 1.4%) of those expected from therapeutic doses given directly to infants. Potential risk of adverse reactions from this low exposure level seem to be outweighed by the benefits of breast-feeding.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Breast Feeding*
  • Female
  • Humans
  • Infant
  • Ketoconazole / pharmacokinetics*
  • Ketoconazole / therapeutic use
  • Milk, Human / chemistry*
  • Mycoses / drug therapy*
  • Time Factors

Substances

  • Ketoconazole