Utility of fragmented human fetal tissue as a potential dopaminergic brain graft in Parkinson's disease

Stereotact Funct Neurosurg. 1993;61(1):1-11. doi: 10.1159/000100616.

Abstract

There is increasing interest in the use of human fetal dopaminergic tissue as a source of striatal transplant in parkinsonian patients. This tissue is acquired by elective abortions. The possibilities of the use of this tissue were studied by macroscopical examination, cell-culturing followed by immunohistochemical staining and by high performance liquid chromatography. It turned out that 50% of the curettages obtained by suction abortion were too fragmented to reliably recognize the dopamine-containing area (ventral mesencephalon). Furthermore, dissection of the brainstem immediately after the abortion procedure seemed to be of utmost importance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Tissue Transplantation*
  • Cell Division / physiology
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Corpus Striatum / transplantation
  • Dopamine / analysis
  • Dopamine / physiology*
  • Fetal Tissue Transplantation*
  • Humans
  • Immunohistochemistry
  • Parkinson Disease / surgery*
  • Staining and Labeling
  • Tissue Donors

Substances

  • Dopamine