Cell kinetic investigations in craniopharyngioma: preliminary results and considerations

Pediatr Neurosurg. 1994:21 Suppl 1:21-3. doi: 10.1159/000120857.

Abstract

In vitro determination of 3H-thymidine labeling index (LI%) was carried out in craniopharyngiomas from 16 patients submitted to repeated surgical procedures. This study showed a poor correlation between LI% values and prognosis, but allowed to detect a high LI% variation in the same tumor investigated in serial different times. The spatial distribution of S-phase proliferative cells in squamous epithelium of cystic components suggests a rationale for intracavitary treatment of cystic and mixed craniopharyngioma and may help explain its success.

MeSH terms

  • Adolescent
  • Adult
  • Bleomycin / administration & dosage
  • Cell Division / drug effects
  • Cell Division / physiology*
  • Cell Division / radiation effects
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Craniopharyngioma / drug therapy
  • Craniopharyngioma / pathology*
  • Craniopharyngioma / radiotherapy
  • Craniopharyngioma / surgery
  • Female
  • Humans
  • Injections, Intralesional
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / radiotherapy
  • Neoplasm Recurrence, Local / surgery
  • Pituitary Gland / drug effects
  • Pituitary Gland / pathology
  • Pituitary Irradiation
  • Pituitary Neoplasms / drug therapy
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / radiotherapy
  • Pituitary Neoplasms / surgery
  • Radiotherapy, Adjuvant
  • Stereotaxic Techniques
  • Treatment Outcome

Substances

  • Bleomycin