Objective: To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.
Design: A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Setting: Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
Subjects: One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Results: Genotypic and gene frequencies were not significantly different in the seven groups examined.
Conclusion: There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.