A disulphide-reinforced structural scaffold shared by small proteins with diverse functions

Nat Struct Biol. 1995 Oct;2(10):835-7. doi: 10.1038/nsb1095-835.

Abstract

We describe the T-knot scaffold, a structural feature shared by the EGF-like proteins, alpha-toxins and proteinase inhibitors from plants.

Publication types

  • Letter

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carboxypeptidases / antagonists & inhibitors
  • Disulfides / chemistry*
  • Epidermal Growth Factor / chemistry
  • Factor IX / chemistry
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Plant Proteins / chemistry
  • Protease Inhibitors / chemistry
  • Protein Conformation
  • Proteins / chemistry*
  • Sequence Homology, Amino Acid
  • Toxins, Biological / chemistry

Substances

  • Disulfides
  • Plant Proteins
  • Protease Inhibitors
  • Proteins
  • Toxins, Biological
  • Epidermal Growth Factor
  • Factor IX
  • Carboxypeptidases