Ureaplasma urealyticum (UU) infection during pregnancy may result in poor outcome. Placentae from 116 normal healthy pregnancies were cultured for UU with a recovery rate of 28.45%. 94 cases ended by normal vaginal delivery had a UU positive rate of 29.79%. The UU positive rate of 22 placenta from cases by cesarean section was 22.73%. The 2 positive rates showed no difference of significance (P > 0.05). This result indicated that UU infection of the placenta was present before passing through the birth canal and not due to contaminant during delivery. The birth weight of the neonates with positive UU infection was on the average 2,919g, while that in the negative UU cases was 3,490g, being 571g higher than in the positive group (P < 0.01). This study showed that placental infection with UU is associated with a low birth weight.