Dobutamine stress echocardiography predicts early wall motion improvement after elective percutaneous transluminal coronary angioplasty

Am J Cardiol. 1995 Oct 1;76(10):652-6. doi: 10.1016/s0002-9149(99)80191-x.

Abstract

In 24 patients with chronic coronary artery disease, dobutamine stress echocardiography (DSE) was performed within 2 days before and after successful elective percutaneous transluminal coronary angioplasty (PTCA) in a blinded fashion. Patients with ischemic response on DSE before PTCA had significant improvement in the global peak-dose DSE score index after PTCA (1.62 +/- 0.35 to 1.40 +/- 0.29, p < 0.001), whereas patients without ischemic response had no improvement. The positive and negative predictive values of pre-PTCA DSE on early myocardial ischemia relief after angioplasty were 93% and 80%, respectively. In patients showing contractility recruitment during low-dose dobutamine infusion in the DSE before PTCA, there was significant improvement in the global resting wall motion score index in the DSE after PTCA (1.48 +/- 0.43 to 1.34 +/- 0.33, p = 0.004), while patients without contractility recruitment showed no improvement. Again, the positive and negative predictive values of pre-PTCA DSE on early hibernation recovery following angioplasty were 80% and 89%, respectively. In conclusion, DSE in patients with chronic, stable coronary artery disease accurately predicts wall motion improvement after successful angioplasty, and the expected improvement is safely demonstrated early after the procedure.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Angioplasty, Balloon, Coronary*
  • Chi-Square Distribution
  • Coronary Disease / diagnostic imaging
  • Coronary Disease / physiopathology
  • Coronary Disease / therapy*
  • Dobutamine*
  • Echocardiography
  • Exercise Test
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Contraction*
  • Predictive Value of Tests
  • Prospective Studies

Substances

  • Dobutamine