Manic-depression and the norepinephrine transporter gene

Hum Hered. 1995 May-Jun;45(3):165-8. doi: 10.1159/000154279.

Abstract

Six multigenerational pedigrees containing multiple cases of manic-depression were genotyped with a DNA polymorphism for the norepinephrine transporter (NET) gene. Using both parametric and nonparametric methods, no evidence of linkage between manic-depression and the NET gene was found.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Bipolar Disorder / genetics*
  • Carrier Proteins / genetics*
  • Female
  • Humans
  • Lod Score*
  • Male
  • Norepinephrine Plasma Membrane Transport Proteins
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Symporters*

Substances

  • Carrier Proteins
  • Norepinephrine Plasma Membrane Transport Proteins
  • SLC6A2 protein, human
  • Symporters