S fimbriae of uropathogenic Escherichia coli bind to primary human renal proximal tubular epithelial cells but do not induce expression of intercellular adhesion molecule 1

B Kreft; M Placzek; C Doehn; J Hacker; G Schmidt; G Wasenauer; M R Daha; F J van der Woude; K Sack

doi:10.1128/iai.63.8.3235-3238.1995

S fimbriae of uropathogenic Escherichia coli bind to primary human renal proximal tubular epithelial cells but do not induce expression of intercellular adhesion molecule 1

Infect Immun. 1995 Aug;63(8):3235-8. doi: 10.1128/iai.63.8.3235-3238.1995.

Authors

B Kreft¹, M Placzek, C Doehn, J Hacker, G Schmidt, G Wasenauer, M R Daha, F J van der Woude, K Sack

Affiliation

¹ Klinik für Innere Medizin, Medizinischen Universität zu Lübeck, Germany.

Abstract

We have recently reported an increase of expression of the intercellular adhesion molecule 1 by renal carcinoma cells in response to S fimbriae of Escherichia coli. Now we demonstrate that E. coli expressing S and P fimbriae strongly binds to human proximal tubular epithelial cells. However, in primary and simian virus 40-transfected renal tubular epithelial cells S fimbriae do not enhance the expression of intercellular adhesion molecule 1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Adhesion*
Epithelium / microbiology
Escherichia coli / pathogenicity*
Escherichia coli Infections / microbiology*
Fimbriae, Bacterial / metabolism*
Humans
In Vitro Techniques
Intercellular Adhesion Molecule-1 / metabolism*
Interferon-gamma / pharmacology
Kidney Tubules, Proximal / microbiology*
Urinary Tract Infections / microbiology*

Substances

Intercellular Adhesion Molecule-1
Interferon-gamma