Amphitoxin, a new high molecular weight antifeedant pyridinium salt from the Caribbean sponge Amphimedon compressa

J Nat Prod. 1995 May;58(5):647-52. doi: 10.1021/np50119a002.

Abstract

A new polymeric pyridinium alkaloid named amphitoxin [2] has been isolated from Amphimedon compressa, and its structure determined by spectroscopic analysis. In laboratory feeding experiments, crude extracts and purified amphitoxin [2] from A. compressa at lower than natural concentration levels effectively deterred feeding of a generalist predatory Caribbean reef fish, Thalassoma bifasciatum.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Chromatography, Ion Exchange
  • Feeding Behavior / drug effects*
  • Fishes / physiology
  • Magnetic Resonance Spectroscopy
  • Marine Toxins / chemistry
  • Marine Toxins / isolation & purification
  • Marine Toxins / pharmacology*
  • Molecular Structure
  • Molecular Weight
  • Porifera / chemistry*
  • Pyridinium Compounds / chemistry
  • Pyridinium Compounds / isolation & purification
  • Pyridinium Compounds / pharmacology*
  • Spectrophotometry, Ultraviolet

Substances

  • Marine Toxins
  • Pyridinium Compounds
  • amphitoxin