Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops

J Toxicol Clin Toxicol. 1995;33(5):463-5. doi: 10.3109/15563659509013755.

Abstract

A patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levels were severely depressed and symptoms resolved spontaneously following discontinuation of the eye drops.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cholinesterases / blood
  • Echothiophate Iodide / adverse effects*
  • Echothiophate Iodide / therapeutic use
  • Female
  • Glaucoma / drug therapy
  • Humans
  • Muscle Hypotonia / chemically induced*
  • Muscle, Skeletal / drug effects
  • Myasthenia Gravis / blood
  • Myasthenia Gravis / diagnosis
  • Ophthalmic Solutions / adverse effects

Substances

  • Ophthalmic Solutions
  • Echothiophate Iodide
  • Cholinesterases