Abstract
Moderately penicillin-resistant Neisseria meningitidis is rare in North America. We report an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada, with serogroup C N. meningitidis. The MICs of penicillin ranged from 0.12 to 0.25 micrograms/ml, and all isolates showing decreased susceptibility had identical genomic fingerprints when they were compared by pulsed-field gel electrophoresis. Our data indicate that N. meningitidis that is moderately resistant to penicillin is prevalent in Saskatchewan, Canada.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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DNA Fingerprinting
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DNA, Bacterial / genetics
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DNA, Bacterial / isolation & purification
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Disease Outbreaks
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Electrophoresis, Gel, Pulsed-Field
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Female
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Humans
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Infant
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Male
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Meningitis, Meningococcal / drug therapy*
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Meningitis, Meningococcal / epidemiology
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Meningitis, Meningococcal / microbiology
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Neisseria meningitidis / classification
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Neisseria meningitidis / drug effects*
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Neisseria meningitidis / genetics
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Penicillin Resistance*
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Saskatchewan / epidemiology
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Serotyping