Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate

J Med Chem. 1993 May 14;36(10):1505-8. doi: 10.1021/jm00062a027.
No abstract available

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Delavirdine
  • Indoles / chemical synthesis*
  • Indoles / pharmacology
  • Piperazines / chemical synthesis*
  • Piperazines / pharmacology
  • Reverse Transcriptase Inhibitors*
  • Structure-Activity Relationship
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Indoles
  • Piperazines
  • Reverse Transcriptase Inhibitors
  • Delavirdine