Histological examination of the gadolinium-enhanced dura mater around meningiomas on magnetic resonance imaging

Neurol Med Chir (Tokyo). 1993 Jul;33(7):429-33. doi: 10.2176/nmc.33.429.

Abstract

Magnetic resonance imaging often demonstrates gadolinium (Gd) enhancement of the dura mater around meningiomas. The Gd-enhanced dura mater was histologically investigated to detect meningioma cells. Gd enhancement of the dura mater occurred in 11 (79%) of the 14 meningiomas studied, and extended as far as 35 mm from the tumor. Histological examination revealed generation of vascular-rich loose connective tissue at the surface of the dura in all five tumors examined. Some clusters of meningothelial cells were distributed in the loose connective tissue in three of the five specimens, and one cluster was obviously neoplastic. These observations suggest that clusters of meningioma cells occur in the Gd-enhanced dura mater around meningiomas.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Brain / drug effects
  • Brain / pathology*
  • Brain / surgery
  • Brain / ultrastructure
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery
  • Brain Neoplasms / ultrastructure
  • Dura Mater / cytology*
  • Dura Mater / drug effects*
  • Dura Mater / surgery
  • Dura Mater / ultrastructure
  • Female
  • Gadolinium*
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging / methods*
  • Male
  • Meningioma / diagnosis*
  • Meningioma / pathology*
  • Meningioma / surgery
  • Meningioma / ultrastructure
  • Middle Aged

Substances

  • Gadolinium