Abstract
Eukaryotic cells transformed with a plasmid expression vector are able to synthesize and assemble HBsAg, a complex multimeric lipoprotein particle. Hybrid particles carrying HIV1 antigenic determinants were constructed and injected into monkeys. A complete immune response including neutralizing antibodies, proliferative and cytotoxic T-cell activities was obtained. Thus, such HIV/HBsAg hybrid particles could be a new approach to multivalent vaccination.
MeSH terms
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Acquired Immunodeficiency Syndrome / prevention & control*
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Animals
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Antibody Formation
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Drug Carriers / therapeutic use
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Epitopes / genetics
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Epitopes / immunology
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HIV Antibodies / blood
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HIV Antigens / genetics
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HIV Antigens / immunology
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HIV-1 / genetics
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HIV-1 / immunology
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Hepatitis B / prevention & control*
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Hepatitis B Antibodies / blood
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Hepatitis B Surface Antigens / genetics
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Hepatitis B Surface Antigens / immunology
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Immunity, Cellular
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Macaca
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Rabbits
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Recombinant Fusion Proteins / immunology
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Vaccines, Synthetic / therapeutic use*
Substances
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Drug Carriers
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Epitopes
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HIV Antibodies
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HIV Antigens
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Recombinant Fusion Proteins
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Vaccines, Synthetic