Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats

Neurosci Lett. 1994 Dec 5;182(2):243-6. doi: 10.1016/0304-3940(94)90807-9.

Abstract

The cellular source of interleukin-6 (IL-6) in brain has not been identified. Using a sensitive, non-radioactive in situ hybridization technique, the cellular localization of IL-6 mRNA in different areas of the rat brain was analysed. Intense staining for IL-6 mRNA was found in Purkinje cells and hippocampal neurons. Our data support an essential role of IL-6 for cerebellar and hippocampal neuron differentiation and function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebellum / physiology*
  • Gene Expression
  • Hippocampus / physiology*
  • In Situ Hybridization
  • Interleukin-6 / genetics*
  • Male
  • Neurons / physiology*
  • Purkinje Cells / physiology
  • RNA, Messenger / genetics
  • Rats

Substances

  • Interleukin-6
  • RNA, Messenger