Molecular mechanisms and genetics of hyaluronan biosynthesis

Int J Biol Macromol. 1994 Dec;16(6):283-6. doi: 10.1016/0141-8130(94)90056-6.

Abstract

Hyaluronan is an extremely important polysaccharide from both the biological and commercial points of view. This review summarizes the present state of the art concerning the polymer and our understanding of the molecular mechanisms of its synthesis with emphasis on the implications of this understanding for polysaccharide engineering of hyaluronan.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Biological Transport
  • Biopolymers / biosynthesis
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Glucose / metabolism
  • Glucuronosyltransferase / genetics*
  • Glucuronosyltransferase / metabolism
  • Glycosyltransferases*
  • Hyaluronan Synthases
  • Hyaluronic Acid / biosynthesis*
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / genetics
  • Industrial Microbiology
  • Membrane Proteins*
  • Molecular Weight
  • Operon
  • Recombinant Proteins / biosynthesis
  • Streptococcus / genetics*
  • Streptococcus / metabolism
  • Transferases*
  • UTP-Glucose-1-Phosphate Uridylyltransferase / genetics*
  • UTP-Glucose-1-Phosphate Uridylyltransferase / metabolism
  • Uridine Diphosphate Glucose Dehydrogenase / genetics*
  • Uridine Diphosphate Glucose Dehydrogenase / metabolism
  • Xenopus Proteins*

Substances

  • Bacterial Proteins
  • Biopolymers
  • Membrane Proteins
  • Recombinant Proteins
  • Xenopus Proteins
  • Hyaluronic Acid
  • Uridine Diphosphate Glucose Dehydrogenase
  • Transferases
  • Glycosyltransferases
  • Glucuronosyltransferase
  • HAS1 protein, Xenopus
  • Hyaluronan Synthases
  • UTP-Glucose-1-Phosphate Uridylyltransferase
  • Glucose