Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists

J Med Chem. 1995 Apr 14;38(8):1259-63. doi: 10.1021/jm00008a002.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Cloning, Molecular
  • Dioxoles / administration & dosage
  • Dioxoles / pharmacokinetics
  • Dioxoles / pharmacology*
  • Endothelin Receptor Antagonists*
  • Humans
  • Male
  • Peptides / pharmacology
  • Rabbits
  • Rats
  • Rats, Wistar
  • Receptor, Endothelin A
  • Receptors, Endothelin / genetics
  • Structure-Activity Relationship

Substances

  • Dioxoles
  • Endothelin Receptor Antagonists
  • PD 155080
  • PD 156707
  • Peptides
  • Receptor, Endothelin A
  • Receptors, Endothelin