Preparation of organic solvent-tolerant mutants from Pseudomonas aeruginosa strain PAO1161

Biosci Biotechnol Biochem. 1994 Sep;58(9):1754-5. doi: 10.1271/bbb.58.1754.

Abstract

Most organic solvents (OSs) are toxic and inhibit growth of microorganisms even at low concentrations. Therefore, they are used to sterilize microbial cultures and to maintain solutions in a sterile condition. However, the physiological basis of such phenomenon is poorly understood. Although there are some microorganisms that can utilize a number of OSs as their sole carbon and energy sources, OSs must be provided as a vapor or at a very low concentration to avoid growth inhibition.

MeSH terms

  • Drug Tolerance
  • Hexanes / toxicity*
  • Mutation*
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / genetics*
  • Solvents
  • Xylenes / toxicity*

Substances

  • Hexanes
  • Solvents
  • Xylenes
  • n-hexane
  • 4-xylene