Synthesis and antimicrobial activity of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones

M V Diurno; A Cristinziano; O Mazzoni; E Piscopo; A Bolognese

Synthesis and antimicrobial activity of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones

Farmaco. 1995 Feb;50(2):143-8.

Authors

M V Diurno¹, A Cristinziano, O Mazzoni, E Piscopo, A Bolognese

Affiliation

¹ Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli Federico II, Italy.

PMID: 7766278

Abstract

A series of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-one s 1a-20a, was synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram- bacteria and Fungi, was tested. The compounds 8a, 13a, 14a, 18a and 6a, 9a, 10a showed remarkable activity respectively against Pseudomonas aeruginosa and against Fungi.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Azetidines / chemical synthesis*
Azetidines / chemistry
Azetidines / pharmacology
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antifungal Agents
Azetidines