Intestinal T-cell lymphoma with massive tissue and blood eosinophilia mediated by IL-5

Leuk Lymphoma. 1995 Mar;17(1-2):155-61.

Abstract

A case of enteropathy associated T-cell lymphoma (EATCL) in a 62-year-old female with a previous history of coeliac disease, complicated during the clinical course by massive blood and tissue eosinophilia is described. The patient's serum contained a factor capable of stimulating the in vitro growth of eosinophilic colonies (CFU-Eo), that was absent in the serum of normal donors. We suggest that such factor was Interleukin-5 (IL-5), as indicated by the presence in the monoclonal tumor T cells of IL-5 encoding mRNA, usually absent in the normal enterocytes of the jejunum.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division / physiology
  • DNA, Neoplasm / analysis
  • Eosinophilia / blood*
  • Eosinophilia / etiology*
  • Female
  • Flow Cytometry
  • Hematopoietic Stem Cells / cytology
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Interleukin-5 / genetics
  • Interleukin-5 / pharmacology*
  • Intestinal Neoplasms / blood*
  • Intestinal Neoplasms / complications*
  • Intestinal Neoplasms / pathology
  • Lymphoma, T-Cell / blood*
  • Lymphoma, T-Cell / complications*
  • Lymphoma, T-Cell / pathology
  • Middle Aged
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics

Substances

  • DNA, Neoplasm
  • Interleukin-5
  • RNA, Messenger