[Angiotensin II induces c-fos and c-myc proto-oncogene expression in the left ventricle]

Sheng Li Xue Bao. 1995 Feb;47(1):59-64.
[Article in Chinese]

Abstract

In the present study, the effects of angiotension II on the expression of protooncogene c-fos and c-myc in the left ventricle were investigated on Langedorff heart preparations. It was observed that angiotensin induced both c-fos and c-myc expression in a dose-dependent manner and the c-fos expression showed an earlier appearance than c-myc. All these induced expressions were blocked by a Angiotensin II receptor antagonist saralasin. The Angiotensin II induced expression of c-fos was also blocked by TTX, but the c-myc gene expression was unaffected.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / pharmacology*
  • Animals
  • Gene Expression / drug effects
  • Genes, fos*
  • Genes, myc*
  • Heart Ventricles
  • In Vitro Techniques
  • Male
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Saralasin / pharmacology
  • Tetrodotoxin / pharmacology

Substances

  • RNA, Messenger
  • Angiotensin II
  • Tetrodotoxin
  • Saralasin