A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases

J Neurol. 1995 Mar;242(4):239-42. doi: 10.1007/BF00919597.

Abstract

Paired samples of cerebrospinal fluid (CSF) and serum from 17 patients with human T-cell lymphotrophic virus I (HTLV-I)-associated myelopathy, 5 patients with multiple sclerosis and 11 controls with non-inflammatory disorders (migraine, idiopathic epilepsy and myelopathy of unknown aetiology) were examined by enzyme-linked immunosorbent assay for the presence of the 60-kDa soluble form of tumour necrosis factor receptor (sTNF-R). The results were compared with blood-CSF barrier function, cell count and the intrathecal synthesis of HTLV-I antibodies. No correlation could be demonstrated. High levels of sTNF-R were found in CSF of patients with HTLV-I-associated myelopathy and multiple sclerosis. In addition, intrathecal sTNF-R was also detected in the patients with non-inflammatory diseases, indicating that sTNF-R is definitively a normal constituent of CSF.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood-Brain Barrier*
  • Cell Count
  • Central Nervous System Diseases / blood*
  • Central Nervous System Diseases / cerebrospinal fluid*
  • HTLV-I Antibodies / biosynthesis
  • HTLV-I Antibodies / cerebrospinal fluid
  • Humans
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / cerebrospinal fluid*
  • Paraparesis, Tropical Spastic / blood*
  • Paraparesis, Tropical Spastic / cerebrospinal fluid*
  • Receptors, Tumor Necrosis Factor / analysis*
  • Solubility

Substances

  • HTLV-I Antibodies
  • Receptors, Tumor Necrosis Factor