Rhabdomyosarcoma and other soft tissue sarcomas of childhood

Curr Opin Oncol. 1994 Jul;6(4):397-402. doi: 10.1097/00001622-199407000-00012.

Abstract

The past year has seen the publication of several important findings regarding the epidemiology, molecular biology, and treatment of pediatric rhabdomyosarcoma and other childhood soft tissue sarcomas. These research advances will help us better understand the mechanisms involved in tumor development and progression, tailor therapy according to specific pretreatment tumor biologic characteristics, and develop novel treatments for rhabdomyosarcoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Diagnostic Imaging
  • Drug Screening Assays, Antitumor
  • Female
  • Genes, Retinoblastoma
  • Humans
  • Incidence
  • Infant
  • Male
  • Neoplasms, Radiation-Induced
  • Neoplasms, Second Primary
  • Oncogene Proteins, Fusion / genetics
  • Prognosis
  • Rhabdomyosarcoma* / diagnosis
  • Rhabdomyosarcoma* / epidemiology
  • Rhabdomyosarcoma* / genetics
  • Rhabdomyosarcoma* / pathology
  • Rhabdomyosarcoma* / therapy
  • Soft Tissue Neoplasms* / diagnosis
  • Soft Tissue Neoplasms* / epidemiology
  • Soft Tissue Neoplasms* / genetics
  • Soft Tissue Neoplasms* / pathology
  • Soft Tissue Neoplasms* / therapy
  • Transcription Factors / genetics
  • Treatment Outcome
  • Whole-Body Irradiation

Substances

  • Oncogene Proteins, Fusion
  • Transcription Factors