Effect of phase modulation on the temperature distribution of a microwave hyperthermia antenna array in vivo

Int J Hyperthermia. 1994 Sep-Oct;10(5):691-705. doi: 10.3109/02656739409022448.

Abstract

Perfused, canine skeletal muscle and the brain tumour of a cancer patient were heated with an array of four parallel, interstitial antennas placed on the corners of a 2-cm square and driven at 915 MHz. The temperature distributions along the axial and diagonal catheters were measured with equal-phase driving of the antennas and with several time-varying schemes of driving phase differences among the antennas. When equal-phase driving was replaced by a rotating scheme of 90 degrees driving phase differences, the tissue area in the junction plane heated above a normalized index temperature of 0.6 increased by a factor of about 1.25. With a rotating phase of 135 degrees, the same area increased by a factor of about 1.6. The axial temperature distribution was not affected significantly by driving phase.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biophysical Phenomena
  • Biophysics
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / therapy
  • Dogs
  • Female
  • Glioblastoma / physiopathology
  • Glioblastoma / therapy
  • Humans
  • Hyperthermia, Induced / instrumentation*
  • Hyperthermia, Induced / methods
  • Microwaves / therapeutic use*
  • Middle Aged
  • Models, Biological
  • Muscles / physiology
  • Temperature