Abstract
Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity against KB and VERO cell lines. Fractionation of seeds extracts was mainly guided by means of a biocidal assay against Artemia salina nauplii. The biological activities resulted from extract-isolated acetogenins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antiprotozoal Agents / pharmacology*
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Artemia / drug effects
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Chlorocebus aethiops
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Drug Screening Assays, Antitumor
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Humans
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Leishmania / drug effects
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Plants, Medicinal / chemistry*
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Seeds
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei brucei / drug effects
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Tumor Cells, Cultured
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Vero Cells
Substances
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Trypanocidal Agents