Spontaneous adrenal and hepatic myelolipomas in the common marmoset

Toxicol Pathol. 1994 Jul-Aug;22(4):440-5. doi: 10.1177/019262339402200410.

Abstract

Myelolipomas occurring simultaneously in the adrenal and liver were found in a 2.7-yr-old, bred female common marmoset (Callithrix jacchus). The animal bore single adrenal and multiple hepatic myelolipomas. The adrenal myelolipoma consisted of mature adipose cells and focal collections of normal hematopoietic elements and was unencapsulated. In the liver, the myelolipomas, which were partially encapsulated, included a large amount of hematopoietic tissue and adipose cells that resembled normal bone marrow cells in various ways. Additionally, one of the multiple nodules contained several bony spicules with osteoblasts. Furthermore, there were invasive figures of hematopoietic cells, such as myeloblasts, erythroblasts, and megakaryocytes, in the hepatic sinusoids around the lesions. Thus, this case has some unusual morphological characteristics and is the first report, to our knowledge, on multiorganic myelolipomas in common marmosets.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / pathology
  • Adrenal Gland Neoplasms / veterinary*
  • Animals
  • Callithrix*
  • Female
  • Liver Neoplasms / pathology
  • Liver Neoplasms / veterinary*
  • Monkey Diseases / pathology*
  • Myelolipoma / pathology
  • Myelolipoma / veterinary*