Induction of c-fos-like protein in the spinoparabrachial tract-neurons locating within the sacral parasympathetic nucleus in the rat

Brain Res. 1994 Oct 3;659(1-2):283-6. doi: 10.1016/0006-8993(94)90894-x.

Abstract

Immunoreactivity against c-fos-like protein (FOS) was induced in many neuronal cell bodies within the sacral parasympathetic nucleus (SPN) in urethane-anesthetized rats by chemical irritation of the urinary bladder with formalin. More than half of these FOS-immunoreactive neurons were retrogradely labeled with Fluoro-Gold injected into the lateral parabrachial nucleus (PBN1). The results indicate that some neurons within the SPN may transmit noxious information from the urinary bladder to the PBN1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Fluorescent Dyes
  • Formaldehyde / pharmacology
  • Immunohistochemistry
  • Lumbosacral Region
  • Neurons / metabolism*
  • Parasympathetic Nervous System / cytology
  • Parasympathetic Nervous System / metabolism*
  • Proto-Oncogene Proteins c-fos / metabolism*
  • Pyramidal Tracts / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Cord / cytology
  • Spinal Cord / metabolism*
  • Stilbamidines*
  • Urinary Bladder / drug effects
  • Urinary Bladder / physiology

Substances

  • 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
  • Fluorescent Dyes
  • Proto-Oncogene Proteins c-fos
  • Stilbamidines
  • Formaldehyde