Bovine Alu-like sequences mediate transposition of a new site-specific retroelement

Gene. 1995 Jan 23;152(2):261-4. doi: 10.1016/0378-1119(94)00709-2.

Abstract

We describe a new family of 3.1-kb repetitive sequences which is present in the bovine genome. The 5' and 3' ends of the unit are flanked with sequences homologous to the 5' and 3' halves of the bovine Alu-like monomer (BM), respectively. Distribution of the 5' ends of the family members in the genome is not random. They are close to the truncated bovine Alu-like dimer (BD) which, in some cases, is followed by 40-bp repeated sequences containing block A of the RNA polymerase III promoter. The ORFs found within the unit code for peptides homologous to amino-acid sequences characteristic for reverse transcriptases (RT). The family members may be considered as mutant mobile elements whose propagation in the genomes was accomplished by means of a process including site-specific recognition with BD. Because of this, we call this family the bovine dimer-driven family (BDDF).

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • DNA Primers
  • Molecular Sequence Data
  • Repetitive Sequences, Nucleic Acid*
  • Retroelements*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • DNA Primers
  • Retroelements

Associated data

  • GENBANK/Z25525
  • GENBANK/Z25526
  • GENBANK/Z25527
  • GENBANK/Z25528
  • GENBANK/Z25529
  • GENBANK/Z25530