Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum

J Nat Prod. 1994 Nov;57(11):1543-8. doi: 10.1021/np50113a011.

Abstract

Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of protein kinase C.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division / drug effects*
  • Chlorocebus aethiops
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Porifera*
  • Protein Kinase C / antagonists & inhibitors*
  • Recombinant Proteins / antagonists & inhibitors
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology
  • Structure-Activity Relationship
  • Vero Cells

Substances

  • Recombinant Proteins
  • Sesquiterpenes
  • Spiro Compounds
  • corallidictyal A
  • Protein Kinase C