Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment

Acta Haematol. 1994;92(3):154-6. doi: 10.1159/000204209.

Abstract

We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Eosinophils / drug effects
  • Felty Syndrome / blood
  • Felty Syndrome / complications
  • Felty Syndrome / drug therapy*
  • Female
  • Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage*
  • Humans
  • Leukocyte Count / drug effects
  • Neutropenia / blood
  • Neutropenia / drug therapy*
  • Neutropenia / etiology
  • Neutrophils / drug effects
  • Recombinant Proteins / administration & dosage
  • Remission Induction
  • Time Factors

Substances

  • Recombinant Proteins
  • Granulocyte-Macrophage Colony-Stimulating Factor