Sex determination. Turning on sex

Curr Biol. 1994 Nov 1;4(11):1003-5. doi: 10.1016/s0960-9822(00)00226-8.

Abstract

The orphan nuclear receptor, steroidogenic factor 1, is central to the differentiation of male and female mammalian gonads. It controls the fate of the initially bipotential gonad as well as later male-specific functions.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Female
  • Fushi Tarazu Transcription Factors
  • Homeodomain Proteins
  • Humans
  • Male
  • Mice
  • Mice, Knockout
  • Ovary / embryology
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Sex Differentiation / genetics
  • Sex Differentiation / physiology*
  • Steroidogenic Factor 1
  • Testis / embryology
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Y Chromosome

Substances

  • DNA-Binding Proteins
  • Fushi Tarazu Transcription Factors
  • Homeodomain Proteins
  • NR5A1 protein, human
  • Receptors, Cytoplasmic and Nuclear
  • Steroidogenic Factor 1
  • Transcription Factors
  • steroidogenic factor 1, mouse