QSA 10 (idebenone) or probucol supplementation of organ preservation solutions prevents oxygen radical-mediated injury of hepatic microsomes

Transplant Proc. 1995 Feb;27(1):738-40.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine
  • Allopurinol
  • Animals
  • Aryl Hydrocarbon Hydroxylases*
  • Benzoquinones / pharmacology*
  • Blotting, Western
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / analysis
  • Cytochrome P-450 Enzyme System / metabolism
  • Free Radicals
  • Glutathione
  • Glutathione Transferase / analysis
  • Glutathione Transferase / metabolism
  • Insulin
  • Lipid Peroxidation / drug effects*
  • Liver*
  • Male
  • Malondialdehyde / analysis*
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Microsomes, Liver / pathology
  • Organ Preservation / methods*
  • Organ Preservation Solutions*
  • Oxidoreductases, N-Demethylating / analysis
  • Oxidoreductases, N-Demethylating / metabolism
  • Probucol / pharmacology*
  • Raffinose
  • Rats
  • Rats, Wistar
  • Ubiquinone / analogs & derivatives

Substances

  • Benzoquinones
  • Free Radicals
  • Insulin
  • Organ Preservation Solutions
  • University of Wisconsin-lactobionate solution
  • Ubiquinone
  • Malondialdehyde
  • Allopurinol
  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP3A
  • Oxidoreductases, N-Demethylating
  • Glutathione Transferase
  • Glutathione
  • idebenone
  • Adenosine
  • Raffinose
  • Probucol