Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues

A Okada; J M Garnier; S Vicaire; P Basset

doi:10.1016/0378-1119(94)90088-4

Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues

Gene. 1994 Sep 30;147(2):301-2. doi: 10.1016/0378-1119(94)90088-4.

Authors

A Okada¹, J M Garnier, S Vicaire, P Basset

Affiliation

¹ Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

PMID: 7926820
DOI: 10.1016/0378-1119(94)90088-4

Abstract

We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 1 (TIMP-1) from a cDNA library derived from healing skin wounds. The deduced amino acid (aa) sequence shows 66, 35 and 34% identity with human TIMP-1 and TIMP-2, and chicken TIMP-3 aa sequences, respectively. High-level expression of rat TIMP-1 RNA was detected in the skin wounds and in normal ovary.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA, Complementary
Gene Expression
Glycoproteins / genetics*
Humans
Molecular Sequence Data
Rats
Sequence Homology, Amino Acid
Tissue Inhibitor of Metalloproteinases

Substances

DNA, Complementary
Glycoproteins
Tissue Inhibitor of Metalloproteinases

Associated data

GENBANK/U06179