(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model

J Med Chem. 1994 Sep 30;37(20):3197-9. doi: 10.1021/jm00046a001.
No abstract available

MeSH terms

  • Animals
  • Arthritis / chemically induced
  • Arthritis / drug therapy*
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / pharmacology
  • Benzopyrans / therapeutic use
  • Carboxylic Acids / chemical synthesis*
  • Carboxylic Acids / pharmacology
  • Carboxylic Acids / therapeutic use
  • Collagen*
  • Guinea Pigs
  • Humans
  • Leukotriene B4 / antagonists & inhibitors*
  • Leukotriene B4 / metabolism
  • Mice
  • Molecular Structure
  • Neutrophils / metabolism
  • Structure-Activity Relationship

Substances

  • Benzopyrans
  • Carboxylic Acids
  • Leukotriene B4
  • Collagen
  • CP 105696