[The significance of clinical prodromes for dosage estimation after whole-body radiation exposure]

Strahlenther Onkol. 1994 Sep;170(9):538-44.
[Article in German]

Abstract

Background: The triage of victims after radiation injury is complicated by missing dose values and the fact that most tissues react after a latency period.

Patients and methods: We evaluated 63 patients undergoing total body irradiation as conditioning regime before bone marrow transplantation in order to find a relation between prodromal symptoms and dose.

Results: Emesis after radiation exposure hints to doses greater than 1.5 Gy. A rise of body temperature above 37 degrees C up to five hours after exposure is related to doses exceeding 2.5 Gy, while an acute onset of diarrhoea is an indicator of a severe accident with more than 9 Gy.

Conclusion: Besides blood counts and chromosome analyses a careful evaluation of prodromal symptoms can help to classify the severity of radiation accidents.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Adult
  • Bone Marrow Transplantation
  • Bone Neoplasms / complications
  • Bone Neoplasms / therapy
  • Combined Modality Therapy
  • Dose-Response Relationship, Radiation
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid / complications
  • Leukemia, Myeloid / therapy
  • Middle Aged
  • Neuroblastoma / complications
  • Neuroblastoma / therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Radiation Injuries / diagnosis*
  • Radiation Injuries / etiology
  • Radiotherapy Dosage
  • Sarcoma, Ewing / complications
  • Sarcoma, Ewing / therapy
  • Whole-Body Irradiation / adverse effects*