Tumor-localizing fluorescent diagnostic agents without phototoxicity

Photochem Photobiol. 1994 Mar;59(3):366-70. doi: 10.1111/j.1751-1097.1994.tb05049.x.

Abstract

In order to develop tumor-localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT-DO1 and has a molecular formula of m-phthalyl-([13,17-bispropanoic acid-3-ethenyl-8-formylethylidene-7-hydroxy-2,7,12,18-tetramethyl- porphyrinate]-manganese (III))-[3'-ethenyl-8'-formylethylidene-7'-hydroxy-2',7',12',18'-te tramethyl- porphine-13',17'-bispropanoyl aspartic acid]-bishydrazone.

MeSH terms

  • Animals
  • Cricetinae
  • Fluorescent Dyes / chemistry
  • Mesocricetus
  • Neoplasms, Experimental / diagnosis*
  • Photochemistry
  • Photosensitizing Agents* / chemistry
  • Porphyrins* / chemistry

Substances

  • Fluorescent Dyes
  • Photosensitizing Agents
  • Porphyrins