Abstract
The intravenous administration to pentobarbitone-anaesthetized cats of the GABA-B antagonists CGP 46381 and CGP 35348 blocks the longer duration component of the inhibition of lumbar extensor monosynaptic reflexes by tetanic stimulation of low threshold flexor primary afferent fibres. GABA-B receptors thus appear to be associated with this inhibitory process, in addition to bicuculline-sensitive GABA-A receptors associated with shorter duration 'presynaptic' inhibition of reflexes and the depolarization of the terminals of primary afferent fibres.
MeSH terms
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Afferent Pathways / drug effects
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Animals
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Baclofen / antagonists & inhibitors
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Bicuculline / pharmacology
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Cats
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Decerebrate State / physiopathology*
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Depression, Chemical
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GABA Antagonists*
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Organophosphorus Compounds / pharmacology*
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Phosphinic Acids / pharmacology*
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Receptors, GABA / classification
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Receptors, GABA / physiology
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Reflex, Monosynaptic / drug effects*
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Spinal Cord / drug effects*
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Spinal Cord / physiopathology
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Tetany / physiopathology
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gamma-Aminobutyric Acid / physiology*
Substances
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GABA Antagonists
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Organophosphorus Compounds
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Phosphinic Acids
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Receptors, GABA
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3-aminopropyl-cyclohexylmethylphosphinic acid
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gamma-Aminobutyric Acid
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CGP 35348
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Baclofen
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Bicuculline