Abstract
We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic beta-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amyloid / analysis
-
Amyloidosis / complications*
-
Amyloidosis / metabolism
-
Amyloidosis / pathology
-
Autoantibodies / blood*
-
Humans
-
Immunohistochemistry
-
Insulin Resistance / immunology*
-
Islet Amyloid Polypeptide
-
Islets of Langerhans* / chemistry
-
Islets of Langerhans* / pathology
-
Male
-
Middle Aged
-
Pancreatic Diseases / complications*
-
Pancreatic Diseases / metabolism
-
Pancreatic Diseases / pathology
-
Receptor, Insulin / immunology*
-
Ubiquitins / analysis
Substances
-
Amyloid
-
Autoantibodies
-
Islet Amyloid Polypeptide
-
Ubiquitins
-
Receptor, Insulin