Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines

S Niwas; P Chand; V P Pathak; J A Montgomery

doi:10.1021/jm00041a027

Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines

J Med Chem. 1994 Jul 22;37(15):2477-80. doi: 10.1021/jm00041a027.

Authors

S Niwas¹, P Chand, V P Pathak, J A Montgomery

Affiliation

¹ Southern Research Institute, Birmingham, Alabama 35255-5305.

PMID: 8057293
DOI: 10.1021/jm00041a027

Abstract

The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.

MeSH terms

Crystallography, X-Ray
Drug Design
Hypoxanthines / chemistry
Hypoxanthines / pharmacology*
Purine-Nucleoside Phosphorylase / antagonists & inhibitors*

Substances

Hypoxanthines
Purine-Nucleoside Phosphorylase