Loss of heterozygosity in ovarian cancer: detection by PCR and microsatellite polymorphism

Boll Soc Ital Biol Sper. 1994 Apr;70(4):125-8.

Abstract

Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 6*
  • DNA Primers / chemistry
  • DNA, Neoplasm*
  • DNA, Satellite*
  • Female
  • Heterozygote
  • Humans
  • Molecular Sequence Data
  • Ovarian Neoplasms / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Receptors, Estrogen / genetics

Substances

  • DNA Primers
  • DNA, Neoplasm
  • DNA, Satellite
  • Receptors, Estrogen