Short-term changes in lipid and protein metabolism in liver transplants from living-related donors

Am J Surg. 1993 Jul;166(1):32-8. doi: 10.1016/s0002-9610(05)80578-1.

Abstract

The effects of liver transplantation involving living-related donors were investigated in 20 pediatric cases in terms of protein and lipid metabolism using the extent of cholesterol esterification and the levels of total cholesterol, lecithine-cholesterol acyltransferase, apolipoprotein A-I, cholinesterase, and rapid turnover proteins as parameters. Cholesterol esterification increased from preoperative values of 39% +/- 4% to 67% +/- 1% (mean +/- SEM, n = 17) at 3 weeks after liver transplantation in successful cases but decreased from the preoperative value of 45% +/- 10% to 26% +/- 6% (n = 3) at 3 weeks in unsuccessful cases. Cholinesterase, transferrin, and prealbumin levels remained low after 3 weeks even in successful cases. Patients who had partial liver transplantations from living-related donors showed rapid recovery of cholesterol esterification. However, patients with graft livers required an extensive period before normalization of protein metabolism occurred, indicating the necessity for long-term follow-up of recipient development.

MeSH terms

  • Adolescent
  • Apolipoprotein A-I / analysis
  • Apolipoprotein A-I / metabolism
  • Aspartate Aminotransferases / analysis
  • Aspartate Aminotransferases / metabolism
  • Bilirubin / analysis
  • Bilirubin / metabolism
  • Child
  • Child, Preschool
  • Cholesterol / analysis
  • Cholesterol / metabolism
  • Cholesterol Esters / analysis
  • Cholesterol Esters / metabolism
  • Cholinesterases / analysis
  • Female
  • Humans
  • Infant
  • Lipid Metabolism*
  • Liver Transplantation / physiology*
  • Male
  • Phosphatidylcholine-Sterol O-Acyltransferase / analysis
  • Phosphatidylcholine-Sterol O-Acyltransferase / metabolism
  • Prealbumin / analysis
  • Prealbumin / metabolism
  • Proteins / metabolism*
  • Retinol-Binding Proteins / analysis
  • Retinol-Binding Proteins / metabolism
  • Tissue Donors
  • Transferrin / analysis
  • Transferrin / metabolism
  • gamma-Glutamyltransferase / analysis
  • gamma-Glutamyltransferase / metabolism

Substances

  • Apolipoprotein A-I
  • Cholesterol Esters
  • Prealbumin
  • Proteins
  • Retinol-Binding Proteins
  • Transferrin
  • Cholesterol
  • Phosphatidylcholine-Sterol O-Acyltransferase
  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Cholinesterases
  • Bilirubin