Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro

Biochim Biophys Acta. 1994 Mar 3;1211(2):234-8. doi: 10.1016/0005-2760(94)90274-7.

Abstract

The effect of ethanol on hepatic lipoprotein secretion is not fully understood. This study shows that exposure of HepG2 cells to ethanol significantly increases intracellular apolipoprotein B, apo B mRNA and secreted apolipoprotein B. No other agent has been shown to produce such an increase in apolipoprotein B synthesis or apolipoprotein B mRNA levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoproteins B / biosynthesis*
  • Apolipoproteins B / genetics
  • Apolipoproteins B / metabolism
  • Ethanol / pharmacology*
  • Hepatoblastoma
  • Humans
  • Liver / drug effects
  • Liver / metabolism*
  • Liver Neoplasms
  • RNA, Messenger / metabolism
  • Tumor Cells, Cultured

Substances

  • Apolipoproteins B
  • RNA, Messenger
  • Ethanol