Characterization of a novel leucocyte activation antigen recognized by the antibody CMRF-37

Immunol Cell Biol. 1994 Feb;72(1):13-21. doi: 10.1038/icb.1994.3.

Abstract

We describe a novel activation antigen recognized by the monoclonal antibody CMRF-37, which is absent or only weakly expressed on resting cells but is rapidly induced on T cells, B cells and monocytes following stimulation. Its kinetics of expression (12-24 h after the addition of the inductive signal) indicate that it is an early activation antigen. The cellular distribution and expression kinetics of the CMRF-37 antigen differ from other known activation antigens and as such should be a useful marker of human leucocyte activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antigens, CD*
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • B-Lymphocytes / immunology
  • Biomarkers
  • Cell Line
  • Cell Membrane / immunology
  • Cytokines / immunology
  • Electrophoresis, Polyacrylamide Gel
  • Flow Cytometry
  • Humans
  • Lectins, C-Type
  • Lymphocyte Activation*
  • Mice
  • Mice, Inbred BALB C
  • Mitogens / immunology
  • Monocytes / immunology
  • T-Lymphocytes / immunology
  • Tumor Cells, Cultured

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • Biomarkers
  • CD69 antigen
  • Cytokines
  • Lectins, C-Type
  • Mitogens